mackenzie – Jun 15, 2006 12:00 AM

MacKenzie is doing very well. She had some trouble with the noise that summer traffic brings to Ely and the increased traffic to the wolf yard due to summer programs. In response, Dr. Chip Hanson at the Ely Vet clinic recommended that we try a light dose of Chlomipramine, which worked well for MacKenzie in the past, when we had large construction projects such as the pond project. During the heat of summer, and while the wolves haven't completed the shedding process, we are very concerned when a wolf expresses anxiety. Risk of heat stroke if very high under these conditions and at the age of 13, we can't take any risks. Chlomipramine is not a sedative, it is a serotonin re-uptake inhibitor, that allows for higher levels of serotonin in the brain. According to the www.marvistavet.com website, The precise mechanism of action (i.e. exactly how these drugs work) is not known fully but it is believed that they act by increasing the activity of the neurotransmitter “serotonin in the brain. Serotonin, in simple terms, is associated with the cozy, happy feelings of comfort. Clomipramine inhibits the removal of serotonin in the brain so that the serotonin present is present for a longer time. Clomipramine is thus classified a “selective serotonin re-uptake inhibitor or “SSRI. The response in MacKenzie shows a calm, confident wolf, that is much more inclined for social interactions with her fellow wolves and staff. When she's stressed, she becomes more irritable and nervous about anyone or thing approaching her, with a light dose of clomipramine, she's relaxed, allows for full body massages and inspections for ticks, and brushing of excess hair. Her loss of vision most likely contributes to her anxiety, and she deserves to have comforts in the final years of her life. Her photo shows her slightly damp from sitting under the sprinkler hose and with a full dose of fly repellent on her ears. Not as aesthetically appealing as last week's photo, but comfortable.