From The Hindu:
Himalayan wolves, also called as Tibetan wolves, which live at more than 4,000 metres altitudes are genetically distinct from grey wolves, according to a study published in the Journal of Biogeography. The divergence of Himalayan wolves relates to past uplift of the region, the authors of the paper note.
Living at such high altitudes, these wolves have genetically adapted themselves to live in low oxygen (hypoxic) conditions. While effective oxygen availability at sea level is nearly 22%, at 4,000 metres altitude, the effective oxygen availability is nearly half — 12.7%.